Ketamine-Assisted Psychotherapy Combining Drug and Talk for Long-Lasting Outcomes

At Zephyr Medical, under the direction of Dr. Benjamin Portal, we believe that breakthrough treatments deserve thoughtful integration into whole-person care. One of the most exciting innovations in mental health today is ketamine-assisted psychotherapy (KAP)—a powerful approach that pairs the neurobiological effects of ketamine with the lasting benefits of guided talk therapy.

Unlike ketamine infusions alone, KAP creates a therapeutic container where patients not only experience relief from symptoms but also process insights, reframe patterns, and build resilience with the help of an experienced clinician.

Why Combine Ketamine with Psychotherapy?

Ketamine works on the NMDA receptor, enhancing glutamate signaling and rapidly promoting neuroplasticity—the brain’s ability to form new connections. This window of flexibility can make psychotherapy more effective, allowing patients to shift long-held thought patterns and access emotional breakthroughs.

When combined with therapy, ketamine sessions often produce:

  • Deeper insights into personal challenges and healing.
  • Enhanced emotional processing, allowing patients to face trauma with less fear.
  • Greater durability of results, as therapy anchors the ketamine experience into daily life.
  • Reduced reliance on medications, as patients learn new coping strategies and reframe negative cycles.

What to Expect at Zephyr Medical

At our Brooklyn Heights infusion suite, Dr. Portal and the Zephyr team carefully personalize each treatment:

  • Consultation & Assessment – We evaluate mental health history, goals, and suitability for treatment.
  • Infusion Session – Patients receive IV ketamine in a comfortable, monitored setting.
  • Therapy Integration – During and after the infusion, a licensed therapist provides guidance, helping patients explore insights in real time.
  • Ongoing Support – Follow-up sessions reinforce growth, resilience, and long-term stability.

Our patient-centered, “white-glove” experience ensures every individual feels safe, supported, and empowered throughout their journey.

Q&A: Ketamine-Assisted Psychotherapy

Q: How is KAP different from traditional ketamine infusions?
A: Traditional infusions focus on symptom relief, while KAP adds structured psychotherapy, helping patients integrate insights and extend benefits long after the infusion.

Q: What conditions can benefit from KAP?
A: Depression, anxiety, PTSD, chronic stress, and certain forms of treatment-resistant mental health disorders often respond well to KAP.

Q: Is KAP safe?
A: Yes. At Zephyr Medical, treatments are administered by trained clinicians under the supervision of Dr. Benjamin Portal, ensuring safety through careful monitoring and individualized dosing.

Q: How many sessions are typically needed?
A: Many patients see improvement after a series of 4–6 sessions, though the number varies depending on condition and personal goals.

Q: Will I remember the therapy if ketamine alters my state of consciousness?
A: Most patients retain meaningful insights. The altered state often makes it easier to access suppressed emotions and explore them productively with a therapist’s support.

Q: Is KAP covered by insurance?
A: While insurance may not fully cover ketamine, some therapy components may be reimbursable. Our team helps patients explore financing and reimbursement options.


Contact Zephyr Medical

Zephyr Medical
111 Livingston St Suite 1901
Brooklyn, NY 11201
📞 Phone: (646) 727-9977
🌐 zephyrmd.com

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